Malnutrition is the risk factor for anti-tuberculosis drugs liver damage

doi:10.3969/j.issn.1000-6621.2014.01.014

Abstract

Abstract: Tuberculosis is a contagious disease related to malnutrition. Malnutrition can affect synthesis of serum albumin in liver, and also induce or exacerbate drug-induced liver injury. Under the conditions of malnutrition, drug-induced liver injury caused by anti-tuberculosis drugs may lead to hepatic perfusion disorders, reduce the hepatic blood flow and the clearance of drugs, and exacerbate this disease. Therefore, during the treatment for patients with tuberculosis combined with malnutrition, anti-tuberculosis treatment and improvement the nutritional status, should be implemented actively. Improvement of the nutritional status in patients with tuberculosis is very important to reduce drug-induced liver injury and to guarantee anti-tuberculosis treatment performed smoothly.

Key words: Tuberculosis, Malnutrition, Antitubercular agents, Hepatitis, toxic, Risk factors

TAN Shou-yong, QIN Hong-juan, LI Yan-qiong. Malnutrition is the risk factor for anti-tuberculosis drugs liver damage[J]. Chinese Journal of Antituberculosis, 2014, 36(1): 64-66. doi: 10.3969/j.issn.1000-6621.2014.01.014

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